| Local Channels (Sikeston Satellite TV) | | 3 | 3 | WSIL | Programs on ABC include: Brothers & Sisters, Ugly Betty, Jimmy Kimmel Live!, Lost, Castle, The Deep End, Here Come the Newlyweds, Copper, Good Morning America, Belmont Stakes, I Survived a Japanese Game Show, Rose Bowl Game, and Modern Family. | Local | Local |
| 6 | 6 | WPSD | Programs on NBC include: Mercy, VeggieTales, Parks and Recreation, The Apprentice, Day One, Dragon, Miss Universe, Notre Dame home Football games, Today, Chuck, National Football League, America's Got Talent, and Meet the Press. | Local | Local |
| 8 | 8 | WSIU | Programs on PBS include: Ciao Italia, Design Squad, Clifford the Big Red Dog, Angelina Ballerina, Live from Lincoln Center, History Detectives, Life, Franny's Feet, Mister Rogers' Neighborhood, Nightly Business Report, Religion & Ethics Newsweekly, Reading Rainbow, and Thomas and Friends. | Local | Local |
| 9 | - | WQWQ | Programs on CW include: 90210, The Tyra Banks Show, Smallville, Gossip Girl, America's Next Top Model, One Tree Hill, Melrose Place, Supernatural, The Vampire Diaries, and Life Unexpected. | Local | - |
| 12 | 12 | KFVS | Programs on CBS include: Miami Trauma, CBS Evening News, Criminal Minds, Sabrina: The Animated Series, Cold Case, The Mentalist, How I Met Your Mother, CBS Morning News, Noonbory and the Super Seven, Big Brother, The Young and the Restless, Sun Bowl, and 60 Minutes. | Local | Local |
| - | 15 | WKPC | Programs on PBS include: Ciao Italia, Design Squad, Clifford the Big Red Dog, Angelina Ballerina, Live from Lincoln Center, History Detectives, Life, Franny's Feet, Mister Rogers' Neighborhood, Nightly Business Report, Religion & Ethics Newsweekly, Reading Rainbow, and Thomas and Friends. | - | Local |
| 23 | 23 | KBSI | Programs on FOX include: Sons of Tucson, COPS, NASCAR on Fox, Lie to Me, NFL on Fox/Fox NFL Sunday, Bones, Past Life, Family Guy, The Conan O'Brien Show, Bowl Championship Series, So You Think You Can Dance, Our Little Genius, and 24. | Local | Local |
| - | 27 | WTCT | WTCT (TCT) | - | Local |
| 29 | - | WKPD | Programs on PBS include: Ciao Italia, Design Squad, Clifford the Big Red Dog, Angelina Ballerina, Live from Lincoln Center, History Detectives, Life, Franny's Feet, Mister Rogers' Neighborhood, Nightly Business Report, Religion & Ethics Newsweekly, Reading Rainbow, and Thomas and Friends. | Local | - |
| 49 | 49 | WDKA | WDKA (MNT) | Local | Local |
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